Of the host of regenerative therapies, Prolotherapy is considered by most to be the “original” regenerative solution and for many years was our “go to solution.” Prolotherapy solution consists of a concentrated solution of sugar water and local anesthetics, as well as other substances that when injected stimulates a very localized inflammatory response that signals the body to heal itself. This solution also promotes tightening of lax connective tissue often seen in chronic or recurrent sprains and degenerative conditions. By improving joint stability, we can reduce abnormal loading forces around the joints and avoid activating “alarm cells” called mechanoreceptors which cause more pain and result in abnormal compensatory movement patterns. Over time, the domino effect of joint instability can result in irreparable changes to the bone structure of the joint, often leaving surgery as the only treatment option. Thus, Prolotherapy provides a unique service to the body and will be around for a long time to come.